Geoff P. Kelly

This study identifies a volatile anaesthetic binding site in voltage-gated sodium channels, showing it modulates channel function and reduces neuronal excitability.

This study identifies an intrinsically disordered region in LARP6 that restricts conformational flexibility of the La-module, enabling RNA-binding selectivity and promoting cancer cell viability and invasion.

This study determines the crystal structure of Legionella collagen-like protein and reveals its unique binding mechanism for sulphated glycosaminoglycans.

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.