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Preclinical safety and efficacy studies of a new gene therapy approach for patients with severe β-hemoglobinopathies.

The paper identifies a regulatory variant driving microphthalmia by analyzing its effects in mouse models and linking it to FOXE3 expression and ocular development.

This study shows that DNA-binding-independent mechanisms contribute to dFOXO's role in metabolic regulation in Drosophila, as evidenced by altered lipid mobilization and transcriptional changes in metabolic and chromatin regulators during starvation.

The paper identifies ancestry-specific chromatin architecture differences in Alzheimer's Disease using Hi-C and ATAC-seq data from African and European ancestry individuals.

This paper shows that the PF gene explains only 22% of runnering variation in strawberries and demonstrates that genomic prediction for runnering is feasible.

This study identifies three factors that suppress meiotic crossovers near centromeres in Arabidopsis and shows that their mutation increases crossover frequency in these regions.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies three downregulated genes in breast cancer lymph node metastasis and shows their fibroblast-specific roles in maintaining stromal barriers, with therapeutic implications.

This paper identifies key molecular drivers of breast cancer brain metastasis through multi-omics analysis and proposes therapeutic strategies based on gene and miRNA dysregulation.

This paper shows that early-stage sparse testing strategies increase genetic gain in plant breeding by improving selection accuracy and intensity through broader TPE sampling and reduced replication.

The paper introduces the Causal Pivot (CP) method to detect causal genetic variants in complex diseases using structural causal models and applies it to UK Biobank data for three diseases.

ERSAtool provides an intuitive R/Shiny interface for RNA-seq analysis, reducing technical barriers and supporting educational use with comprehensive reporting.

The paper shows that premature termination codons in Zfp423 cause different phenotypes in mice, challenging the assumption that all PTCs are functionally equivalent.

fSuSiE improves fine-mapping of QTLs by modeling spatial genetic effects on molecular traits, achieving higher resolution in identifying causal variants and their molecular targets.

The paper develops a method to estimate enzymatic activities from genetic variants using fitness assays and combines allele effects to predict pathogenicity in recessive diseases.

The paper assesses two multiplexing strategies for CRISPR/Cas9-based gene drives in Anopheles stephensi to overcome target site resistance.

The paper identifies a non-canonical BRCA2 variant in moss that promotes homologous recombination and binds ssDNA without a canonical DNA binding domain.

The paper identifies genomic loci regulating Factor V expression in hepatocytes and megakaryocytes of mice using QTL analysis across multiple strains.

The paper analyzes transcriptomics and metabolomics data from coarse and fine cashmere goats to identify genes and metabolites associated with fiber diameter differences.

The paper shows that disrupting TAD boundaries in the Slc29a3/Unc5b locus causes tissue-specific transcriptional changes in multiple genes.