Na Liu

Matrix stiffness shapes immunometabolic states and response to PD-1 blockade in gastric cancer

This study shows that matrix stiffness in gastric cancer affects immunometabolic states and response to PD-1 blockade, with softer matrices improving treatment efficacy.

Circulating apoB-containing lipoproteins constituted blood-borne innate immune barrier limits ZIKV dissemination and congenital infection risk

The paper identifies apoB-containing lipoproteins as a blood-borne innate immune barrier that restricts ZIKV dissemination and congenital infection risk by blocking viral entry through PS receptor competition.

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy

This paper shows that anti-CTLA-4 antibodies destabilize intratumor Tregs via TGF-β signaling, enhancing anti-tumor immunity and immunotherapy.

A Minimally Invasiveness Hybrid Brain-Computer Interface: A Distributed, Scalable and Evolvable Architecture for Whole Brain Access

This paper introduces a minimally invasive hybrid brain-computer interface that improves signal quality and scalability over existing non-invasive and invasive systems.

Persistent Post-Inflammatory Matrix Stiffening Defines a Premalignant Mechanical Niche in Ulcerative Colitis-Associated Neoplasia

This study identifies persistent post-inflammatory matrix stiffening as a premalignant mechanical niche in UC-associated neoplasia, showing its role in epithelial remodeling and potential therapeutic targeting.

Base-resolution DNA methylome of human MDS hematopoietic stem cell reveals TET2-GFI1 epigenetic axis repressing MDS

The paper maps the base-resolution DNA methylome of human MDS HSCs and identifies a TET2-GFI1 epigenetic axis that regulates HSC homeostasis.

Synora: vector-based boundary detection for spatial omics

Synora identifies tumor-stroma boundaries in spatial omics data using cell coordinates and tumor/non-tumor labels, achieving robust boundary detection across datasets and modalities.

Differential transcriptomics and metabolomics analyses of the skin of coarse and fine Liaoning cashmere goats

The paper analyzes transcriptomics and metabolomics data from coarse and fine cashmere goats to identify genes and metabolites associated with fiber diameter differences.

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

This study reports two cases of maternal malignancies detected incidentally during noninvasive prenatal tests in Asian women, showing concordant genome disruption patterns between tumor samples and NIPT results.