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The paper investigates how an oncogenic lncRNA transgene affects epigenetic memory at a naive chromosomal locus, showing that epigenetic silencing can reverse ectopic CENP-A deposition over time.

The paper functionally characterizes 706 STIM1 EF-hand variants using overexpression fitness costs in human cells, revealing structural and functional constraints and implications for disease.

The paper introduces a copula-based method to model non-linear gene co-expression changes along temporal trajectories in scRNA-seq data, applied to study pituitary development in mice.

The paper introduces SME, a fast method for detecting genome-wide epistasis in large biobank studies by focusing on functionally relevant genomic regions.

This study identifies inflammation-induced alternative splicing in human endothelial cells and links it to cardiovascular disease risk through genetic mechanisms.

This study shows that autophagy gene knockdown in C. elegans affects lifespan in a highly condition-dependent manner, with variable outcomes based on genetic background, temperature, and experimental conditions.

FLOW-MR estimates causal effects of time-varying risk factors using GWAS summary statistics, revealing BMI's childhood protective effect on breast cancer and evolving impacts on stroke risk.

The paper shows that antisense transposon insertions into host genes trigger piRNA-mediated immunity in Drosophila by generating chimeric transcripts that initiate silencing.

This study identifies three genomic regions and 12 candidate genes associated with age at first service in Chinese Holstein heifers using GWAS and colocalization analysis, highlighting ANAPC4 as a putative causal gene.

This study identifies and characterizes the GET complex components in Magnaporthe oryzae, showing their roles in growth, development, and pathogenesis.

This study identifies DIMT-1 as a regulator of C. elegans lifespan and stress resistance through its role in rRNA methylation and germline function.

This study identifies 44 candidate genes for temperature-stable resistance to bacterial wilt in tomato using a new panel and two-reference genome approach.

The paper introduces an IBD mapping method with multiple testing adjustment to associate genome-wide loci with complex traits, showing improved power for rare variants.

The paper introduces a method to predict the direction of phenotypic differences between individuals using genomic data, achieving over 90% accuracy in many cases.

This study shows that PD-L1 from retinal pigment epithelium reprograms microglia to reduce inflammation and protect against retinal degeneration in mouse models.

The paper identifies two functional domains in a genomic region that influence adult migration timing in Chinook salmon, showing how a simple genetic system interacts with genomic backgrounds to generate ecotypic diversity.

The paper identifies genetic determinants of CD8+ T cell receptor (TCR) repertoire in cancer patients before and after immune checkpoint blockade (ICB) treatment, finding associations with HLA alleles and treatment response.

The paper shows eIF4E and NCBP2 have distinct roles in nuclear mRNA processing, influencing different transcript populations and outcomes.

The paper shows that mutations in the CerS homeodomain can either worsen or improve insulin resistance in Drosophila under high sugar diet conditions.

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.