Discover, rate, and discuss biology preprints.

The paper identifies 63 active and 34 putative inactive introns in Trichomonas vaginalis using a new assembly and pipeline, and compares them to its close relative Trichomonas stableri.

This study crosses elite maize inbred lines with wild relatives to enhance genetic diversity, identifying crosses with significant yield improvements and genetic introgression.

This study identifies genetic variants and genes associated with diapause in Drosophila, linking them to olfactory and reproductive systems.

This study uses whole-genome sequencing and genomic prediction to accelerate heartwood formation in oak trees by identifying genetic markers linked to heartwood traits.

This study shows that asp and Sas4 genes in Drosophila affect nuclear structure, chromatin organization, and genome stability, contributing to microcephaly pathogenesis.

Missense3D-PTMdb maps missense variants and PTM sites to AlphaFold 3D models to explore their structural and functional impacts.

This paper extends phase-type theory to time-inhomogeneous coalescent processes, enabling exact computation of moments under diverse demographic scenarios and introduces a software package for parameter estimation.

This paper introduces an expectation-maximization method to infer general diploid selection from time-series genetic data, finding evidence for selection in six genomic regions from ancient DNA samples.

This paper describes a pig model of Angelman syndrome that mirrors early developmental symptoms observed in humans.

The paper identifies characteristics of TP53 variants with reduced penetrance using ClinVar data and a random forest model, finding they have intermediate function, higher frequency, and delayed disease onset.

This paper introduces as-eGRM, a method to reveal ancestry-specific structures in admixed populations by incorporating genealogical trees and local ancestry calls, outperforming existing methods in simulated and empirical datasets.

The paper estimates the probability of finding Y-STR profile matches and related individuals in forensic databases using simulation studies.

This study uses CRISPR/Cas9 to knockout Laccase2 in pea aphids, revealing its essential role in eggshell pigmentation, hardening, and survival during overwintering diapause.

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

The paper demonstrates how quantile regression can correct for subtle population stratification in genome-wide association studies using human height as an example.

The paper develops the first species-specific epigenetic clock for common dolphins using DNA methylation data from stranded and bycaught individuals, showing consistent underestimation in older dolphins.

This paper identifies additional genetic markers influencing eye color in individuals with genotypes not matching their expected phenotype based on rs12913832.

The paper profiles tRNA modifications in Pseudomonas aeruginosa to uncover regulatory networks and validate gene annotations.

This paper models how demographic factors affect the spread and persistence of gene drives in populations.

This study shows methylglyoxal mutagenizes single-stranded DNA through Rev1-mediated slippage and mispairing, with mutations enriched in tumor datasets.