Denise J. Montell

This study identifies RAC1P29S and MERTK as drivers of melanoma cell cannibalism of T cells through a 'grip and gulp' mechanism involving actin dynamics.

This study identifies Rac2 hyperactivity as a cause of neutrophil dysfunction and T cell lymphopenia in patients with RAC2E62K mutations.

The paper systematically analyzes RhoGAP expression and function in Drosophila border cell morphology and migration, showing most RhoGAPs are expressed and functionally required.

This study shows NG2-targeting CAR-Ms engulf glioblastoma cells and block over 85% of their 3D invasion.

This study identifies kinases involved in cellular recovery after caspase activation using a kinome inhibitor screen, revealing roles for adhesion, cytoskeleton, and growth factor signaling.

This paper shows that hyperactive Rac in Drosophila border cells converts sublethal nibbling of nurse cells into lethal phagocytosis, revealing mechanisms that could inform cancer immunotherapy.

This study shows CD47 inhibits Rac-mediated phagocytosis by preventing Vav1 phosphorylation, shifting the mechanism from Rac-based reaching to Rho-based sinking.

This study identifies genetic variants and genes associated with diapause in Drosophila, linking them to olfactory and reproductive systems.

This study shows that cool temperatures induce deep sleep and alter circadian rhythms in Drosophila melanogaster during diapause, with sleep overriding light-aversion behaviors.

This study identifies and characterizes the role of EIF2A in Drosophila spermatogenesis, showing its essential function in male fertility through genetic mutations.

The paper investigates how Drosophila border cells integrate chemical and physical cues during migration, showing that tissue topography significantly influences path selection.

The paper investigates how Wnt, Hedgehog, and Notch signals regulate distinct cell fates in Drosophila follicle precursor cells using quantitative microscopy.