Discover, rate, and discuss biology preprints.

This paper introduces solveblock, a software tool that enables FDR-controlled conditional independence analysis using GWAS summary statistics, leading to additional discoveries in British individuals.

This study compares phase-free and phase-based local ancestry inference methods, finding phase-free methods provide more accurate results despite lower phase quality.

This study examines epigenetic changes in Borrelia-infected ticks, finding increased EHMT2 expression but no change in DNA methylation of specific repeats.

This study identifies transposon activities as key drivers of sweet orange cultivar selection and diversification over the last 500 years.

DNACipher predicts variant effects across cell types and assays, identifying imVars at most GWAS loci with support from experimental data.

This study identifies SAMM50 rs3761472 as a risk factor for MASLD by showing it causes mitochondrial dysfunction and metabolic impairments in mice.

The paper shows that an ATTTC repeat insertion in an Alu element enhances a DAB1 enhancer, leading to neuronal dysfunction in SCA37.

This study identifies SNP markers associated with environmental variables in European beech populations along an altitudinal gradient, highlighting potential genes involved in local adaptation to temperature and precipitation.

This study develops a DNA reference library for elasmobranch species in Sri Lanka using Oxford Nanopore Sequencing for fisheries monitoring and conservation.

The paper describes a high-efficiency method for homology-dependent genome editing in Cryptococcus neoformans using CRISPR/Cas9 and a Ku80 mutant strain.

This paper investigates how geographic breadth of sampling affects the discovery and frequency of rare, deleterious variants in genetic studies.

The paper shows that C. elegans transmit environmental information through lipid changes across generations, affecting offspring thermotolerance via a neuron-intestine-oocyte pathway.

This study identifies diencephalic and neuropeptidergic dysfunction in zebrafish with autism-risk mutations, revealing potential molecular and behavioral mechanisms.

The paper applies the MR-Horse method to reduce selection bias in GWAS of disease progression by accounting for genetic correlation and pleiotropy, showing reduced bias and controlled type 1 error rates.

This study identifies a unique leech species in Nigeria and confirms the presence of the Hirudin gene, suggesting potential for leech therapy.

The paper isolates and analyzes cyclotide genes from Solanaceae plants, showing high sequence identity with reference sequences and providing insights for future cyclotide research.

This study identifies a mutation in the FucTA gene affecting thermal nocifensive escape behaviors in Drosophila larvae.

The paper investigates hybrid sterility in S. cerevisiae x S. uvarum hybrids using meiotic null alleles, finding that near-haploid offspring with mixed chromosomal inheritance can be recovered despite reduced fertility.

This paper describes a cross-species rescue by mating method to study gene essentiality across Saccharomyces species.

The paper identifies a 5 kb deletion causing Sex-linked orange coat color in cats by ectopic Arhgap36 expression, which inhibits PKA and disrupts melanogenic pathways downstream of Mc1r.