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The paper identifies Seo1p as a high-affinity transporter for gamma-Glu-met in yeast and fungi, showing its specificity and role in peptide uptake.

This study assesses genetic variability in hot pepper landraces and an improved genotype in Ethiopia, finding significant phenotypic and genotypic variation with recommendations for high-yielding accessions.

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

The paper uses long-read RNA sequencing to analyze CLN3 transcription complexity and the impact of a common 1-kb deletion in juvenile CLN3 disease, revealing multiple transcripts and isoforms.

The paper identifies genetic variants associated with antibody responses to infectious diseases in Tanzanian dairy cattle using genome-wide association studies.

The paper uses medaka fish to study genetic and environmental interactions in heart rate, identifying QTLs and validating genes, while showing limitations of GWAS in capturing complex genetic effects.

This study identifies genetic variants underlying seven Mendelian traits in pea, revealing new alleles and gene mutations for traits previously poorly understood.

JointPRS improves genetic risk prediction for non-European populations by integrating genetic correlation and multi-population data without individual-level tuning data.

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

The paper develops an AI-enhanced CRISPR prime editing framework for correcting TOR1A mutations in dystonia, showing strong predictive performance and identifying key factors influencing editing efficiency.

The paper introduces CRISPR-CISH, a chromogenic in situ DNA detection method that uses CRISPR/dCas9 to generate target-specific signals visible under bright-field microscopes.

This study shows that experimental GALT mRNA therapy improves motor function in a mouse model of Classic Galactosemia.

The paper identifies a hypomorphic MYRF variant causing partial loss of function in the RPE, with two novel splicing variants linked to isolated nanophthalmos.

This paper investigates the role of C(2)M in Drosophila meiosis, showing its interaction with SMC1 and SMC3 and its role in synaptonemal complex assembly.

This paper estimates that the heritability of human lifespan is about 50% when accounting for extrinsic factors and cutoff age effects, challenging the consensus that genetics has a minor role in lifespan.

The paper identifies DNA damage-associated protein co-expression modules in cardiomyocytes and shows their relationship to genetic variation tolerance and CVD risk.

This study examines how rifampicin-resistance mutations in Bacillus strains affect the synthesis of antioxidant, DNA-protective, and SOS-inhibitory metabolites, finding increased activity in resistant mutants.

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

This paper introduces a system for spatial and temporal control of GFP-tagged protein degradation in mice, demonstrating its application to study the glucocorticoid receptor in the epidermis.