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This paper introduces a spherical-harmonics regression method for PheWAS to detect localized genetic effects and summarize spatial complexity using rotation-invariant descriptors.

This study integrates multi-omics data to identify genes influencing yield in maize, showing improved resolution and predictive power compared to GWAS.

This study identifies TOCA-1 as a regulator of collateral branching in C. elegans neurons, showing it promotes actin assembly through WASP-1 and Arp2/3 complex activation.

The paper develops a theoretical method to analyze complex spatially heterogeneous population models and shows that high environmental spatial autocorrelation promotes the maintenance of locally adaptive alleles.

The paper uses a multiparent yeast population to identify QTL for growth rates across environments, revealing context-dependent genetic architectures and allelic heterogeneity.

The paper identifies genetic loci affecting cocaine sensitivity in Collaborative Cross mouse strains through QTL mapping and proposes candidate genes for further study.

The paper tests a Y-linked Cas9 expression system in Drosophila melanogaster and finds reduced Cas9 activity, suggesting meiotic sex chromosome inactivation.

The paper identifies Zrf1 as an epigenetic factor regulating intestinal stem cell proliferation and genome stability in Drosophila midgut regeneration.

The paper reanalyzes mtDNA mutation data to determine if somatic mutations are under purifying selection, finding that apparent selection signals are due to germline mutations and most somatic mutations are neutral.

This study identifies the skeletal remains of Duke Bela of Macso using multidisciplinary methods, revealing a premeditated assassination with 26 injuries and confirming his royal lineage through DNA analysis.

This study functionally characterizes SATB2 missense variants to identify distinct effects on chromatin binding and transcriptional activity, revealing partial loss-of-function and some variants with increased function.

The paper investigates the role of the alternative complement pathway in Stargardt disease by analyzing Abca4-/- and Cfd-/- mice, finding that while the pathway drives complement activation, it does not reduce lipofuscin accumulation.

The paper directly identifies de novo mobile element insertions in human sperm using long-read sequencing and finds age-related increases in retrotransposition rates.

The paper evaluates genomic prediction models for agronomic traits in perennial ryegrass under genotype x environment interactions, showing improved accuracy when accounting for these interactions.

This study examines how mating status influences exercise response and fitness tradeoffs in female Drosophila, finding that mating affects climbing performance, lifespan, and fertility.

This paper describes a novel meiotic mutant in maize that produces unreduced female gametes, enabling clonal seed production when combined with another mutant, advancing synthetic apomixis research.

The paper introduces PCAN, a resource integrating high-throughput phenotyping of mouse models for Prader-Willi syndrome to evaluate phenotypes and therapeutic strategies.

This study shows that p97 and PML nuclear bodies regulate cGAS degradation after DNA damage, affecting the DNA damage response and senescence.

The paper shows that CLN3 can function independently of WHI5 in regulating cell size for Start in yeast, as the double mutant exhibits near-wild-type cell size.