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The paper presents complete telomere-to-telomere cowpea genomes, revealing centromere evolution and subspecies divergence in Phaseoleae.

This study uses genomic data to show that most multidrug-resistant tuberculosis in Bhutan comes from local transmission, forming a large, recent endemic cluster.

The paper develops MSSPE, a method to enrich low-abundance viruses in wastewater using spiked primers, improving detection in resource-limited settings.

The paper compares short- and long-read sequencing technologies in metagenomics, showing that longer short reads with optimal prep improve assembly and protein detection without needing more sequencing depth.

This study characterizes the evolutionary dynamics of mammalian microRNAs across 73 genomes, revealing conserved and lineage-specific patterns of miRNA family gains and losses.

The paper investigates how neocentromeres reshape chromatin and identifies conserved features of native centromeres using haplotype-resolved assemblies and multi-omics data.

The paper uses single-nuclei RNA sequencing to analyze gonadal tissue from captive-bred and wild-bred male Senegalese sole, identifying impaired Sertoli-spermatogonia interactions as a cause of reduced sperm production and infertility.

This study shows that Dsup protects yeast from DNA damage but has fitness costs and creates new dependencies on DNA repair pathways.

NTv3 is a foundation model that predicts genome function, annotates genes, and designs DNA sequences across species, outperforming existing models in multiple tasks.

This paper introduces a novel genome engineering method for iPSCs that enables efficient multiplex gene editing and clone selection, improving the precision and speed of iPSC-based therapies.

This study shows that APOL1 G1 and G2 risk alleles affect diet-induced obesity severity differently in male and female transgenic mice.

This study uses HITI gene editing in mouse Sertoli cells to restore Cldn11 function and rescue spermatogenesis and fertility in Cldn11-deficient mice.

This study compares transcriptomic profiles of embryonic stem cells across mammals, identifying conserved and species-specific pluripotency mechanisms and markers.

The paper introduces eSPLIT and iSWAP, two methods for generating conditional alleles using short artificial introns, validated in human and mouse models.

This paper creates a 3D epigenomic roadmap of human B-cell differentiation, revealing regulatory mechanisms in immunity and cancer.

The paper identifies two chromatin modules, ACs and DCs, that regulate proinflammatory gene expression through distinct mechanisms in human endothelial cells.

LDscore provides a cloud-based, Python 3 web platform for LDSC analysis, improving accessibility and scalability for heritability and genetic correlation studies.

This study produces high-quality genome assemblies for two Neotropical bumblebee species using long-read sequencing.

QTLIT is a Shiny app that simplifies QTL analysis by integrating SNP identification and visualization tools for plant breeders using DNA sequence data.