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The paper introduces a data repository containing epigenomic data from mice exposed to various environmental toxicants, enabling research on disease susceptibility.

This paper shows that p53 loss in colorectal cancer increases enhancer activity, drives oncogenic pathways, and correlates with poor survival in p53-deficient tumors.

This study examines how early-life exposure to environmental toxicants alters TE chromatin accessibility and expression in mouse liver, revealing exposure-specific and sex-dependent effects.

The paper identifies candidate m6A modification sites on HPV18 early transcripts in HeLa cells using RNA sequencing and perturbation experiments.

This study analyzes DNA fragmentation and methylation in CSF-derived cfDNA from NSCLC-BMET patients and finds distinct patterns compared to controls and plasma-derived cfDNA.

This study uses single-nucleus RNA sequencing to show methamphetamine induces cholesterol metabolism gene upregulation in dopaminergic neurons, with drug-specific effects and potential implications for neuron function.

The paper investigates how centromere divergence and allopolyploidy influence genome evolution in carnivorous sundews, revealing structural differences between species with distinct chromosomal architectures.

The paper improves genome assembly quality assessments by incorporating evolutionary history and introduces a curated set of BUSCOs and phyca software for phylogenetic analysis.

This study shows that uranium mining alters deep groundwater microbiomes, causing genetic and functional changes through increased radiation and uranium exposure.

The paper identifies a new class of proteomes, USURPs, formed by upstream overlapping ORFs that cis-regulate protein-coding sequences and are linked to human diseases.

The paper models shared genomic and environmental influences on cognitive, language, and social traits in children, identifying distinct domains with trait-specific correlations between genetic and environmental factors.

This paper uses rare k-mers to identify centromere haplogroups in human populations and cancer translocations, revealing structural diversity and translocation mechanisms.

This study shows that Near Eastern ancestry in Central Italy arrived during the late Republican period, before the Roman Empire began.

The paper constructs a sorghum pangenome from ex-PVP cultivars and a wild accession, identifying structural variants and selective sweeps linked to adaptation and trait improvement.

This study examines genetic differentiation in Culex tarsalis mosquitoes, showing environmental factors influence their genetic makeup and adaptation to climate change.

This study uses next-generation sequencing to analyze HBV and HDV genotypes and mutations in Peruvian samples, identifying genotype F for HBV and genotype 3 for HDV with associated clinical mutations.

The paper annotates mitochondrial genomes of Neotropical raptors and designs metabarcoding primers for environmental DNA applications to aid conservation.

This paper evaluates how hyperparameters affect prediction stability and performance in genomic prediction for wheat breeding using Gradient Boosting Machines.

The paper investigates somatic mutation variation in walnut clones propagated through different methods, finding high mutation rates and genomic instability in somatic embryos.

The paper shows that disease-associated variants in alternative protein isoforms can cause structural mutations, emphasizing the need to consider tissue-specific expression and full-length transcripts in variant interpretation.