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The paper finds that positive genetic interactions have greater scientific impact but are underrepresented in literature, despite equal detection capability.

This study constructs a reference-free pangenome of Arabidopsis thaliana using 93 assemblies, revealing gene and pseudogene diversity across geographic regions.

This study constructs a transcriptional and epigenetic atlas of T cell development in neonatal and adult mice, identifying age-related gene regulatory programs and a conserved regulator, Zbtb20.

This paper benchmarks three statistical phasing methods using synthetic diploids, finding consistent error patterns across methods and populations.

The paper uses Nanopore duplex sequencing to analyze 5hmC and 5mC distribution in medaka brain DNA, revealing strand-specific patterns in CpG dinucleotides.

MintFlow is a generative AI algorithm that predicts how tissue perturbations reprogram cell states in disease, revealing novel cell populations and therapeutic targets in three human conditions.

This study presents a chromosome-level genome assembly of the spider mite Tetranychus cinnabarinus, identifying key detoxification genes relevant to pesticide resistance.

The paper de novo assembles the genome of Agropyron cristatum and identifies genes for wheat improvement, developing a genome-selection model for breeding derivatives.

This study uses ancient DNA to show genetic continuity and differences in kinship systems among Early Copper Age communities in the Carpathian Basin.

This paper applies HERRO error correction to Oxford Nanopore sequencing data to resolve a neonatal ICU MRSA outbreak at the SNV level, achieving results comparable to Illumina sequencing.

MITScan performs genome-wide association analysis between microbiome and host transcriptome using zero-inflated negative binomial models, achieving computational efficiency with score tests and permutation methods.

The paper analyzes allelic coverage in oysters to identify SNPs associated with polymorphic duplications, finding 15% of variants linked to copy number variations across chromosomes.

The paper introduces a comprehensive database integrating 16S, 23S, and 5S rRNA sequences, alignments, intragenomic heterogeneity, and secondary structures from around 5000 microbial genomes.

This study presents a chromosome-level genome assembly of Pinus massoniana Minlin WY36, revealing insights into conifer evolution and resin synthesis.

This study shows that R-loops maintain promoter architecture and balanced lineage allocation during differentiation by influencing H2A.Z occupancy and chromatin structure in mouse embryonic stem cells.

This study identifies 43 genes linked to centenarians and red wine consumption, highlighting their roles in stress response, apoptosis, and disease pathways associated with longevity.

This study identifies haplotype signatures associated with blanchability in groundnut using GWAS and haplo-pheno analysis, revealing subspecies and agronomic type associations.

The paper improves somatic mutation detection in a highly heterozygous oak genome by using a read assignment strategy, increasing the mutation rate estimate by fivefold.

The paper compares IG/TR loci across 44 mammalian species, finding correlations in gene counts, structural patterns linked to population bottlenecks, and haplotype diversity suggesting limited recombination potential.

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.