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The paper identifies sequence features associated with recursive splicing and develops a classifier to detect these features.

The paper identifies a novel Cas12a variant, BvCas12a, with high specificity and engineers variants with broader PAM compatibility and improved editing efficiency.

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

This study identifies two genes with high nucleotide diversity for species and genetic lineage classification of Citrobacter spp., reducing costs compared to whole-genome sequencing.

This paper introduces AGR, a pipeline to infer paleogenomes from modern species by using inter-species chromosomal synteny and hierarchical clustering.

The paper identifies 5mC-selective deaminases and demonstrates their use in ultra-sensitive methylome sequencing at single-base resolution.

The paper identifies age-related increases in inter-individual gene expression variability using the Gene Stability Score in GTEx data, showing distinct biological impacts and non-random network architecture.

The paper reports the genome of Paramecium aurelia, revealing tiny germline chromosomes with an exceptionally high recombination rate and a new class of Helitrons at their ends.

This study identifies genetic and transcriptional responses of Zymoseptoria tritici to host defense simulations, revealing shared and condition-specific adaptations.

The paper introduces FLEXseq, a methylation sequencing method that enriches and sequences DNA fragments flanking the CCGG motif, showing strong correlation with WGBS and potential for diagnostic applications.

The paper identifies evolutionary gains in bivalent chromatin domains in mammalian spermatogenesis and links their ancestral chromatin states to distinct somatic gene functions.

The paper presents the first genome assembly of Abrothrix olivacea and uses it to study gene expression and genetic divergence in kidney tissue across contrasting environments.

ProtoCloud improves cell type annotation by providing interpretable, uncertainty-aware predictions and better performance on rare cell types across multiple datasets.

The paper identifies locally persistent lineages of STEC O157:H7 that contribute to disease burden and persist for up to 8.6 years in Minnesota.

This study identifies dispersal-specific transcriptional biomarkers in Pseudomonas aeruginosa biofilms by analyzing gene expression across attachment, maturation, and dispersal stages.

The paper identifies genetic variants influencing DNA methylation across tissues and development in mice and humans, revealing two distinct epigenetic programming periods and linking methylation to regulatory elements and disease variants.

CanVAS harmonizes and imputes canine genotype data from multiple sources to create a unified resource for genetic studies.

The paper integrates genome data from Ralstonia solanacearum to identify integration spots linked to adaptive functions and genome plasticity.

This study shows that deleting CK2α in hematopoietic stem cells (HSCs) alters their transcriptome toward an immune-primed state, with tissue-specific effects on inflammatory and immune-related genes.

The paper analyzes single-cell transcriptomes of human islet cells across glycemic states to identify gene expression defects in beta cells associated with type 2 diabetes.