ROCK inhibitor Ripasudil reduces Alzheimer pathological proteins and enhances cellular bioenergetics
Yuehan Li, Zhiqing Liu, Xavier Cambi…·Weiming Xia
This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Yuehan Li, Zhiqing Liu, Xavier Cambi…·Weiming Xia
This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.
Ashley Michelle Campos, Gayathri Batchalli Maruthy, Genevieve Cumming…·Bart Rypma
This study examines how trait mindfulness affects cortisol changes and mood reactivity after a negative mood induction, finding that mindfulness moderates these relationships.
Sebastian Konig, Pauliina Yrjola, Sampsa Vanhatalo, Anton Tokariev
The paper examines how cortical bursts influence phase synchrony development in preterm infants and links persistent phase-based connectivity to poorer neurocognitive outcomes.
Elizabeth Riley, Senegal Alfred Mabry, Mary Katherine MacMillan…·Adam K Anderson
This study investigates how a genetic polymorphism in ADRA2B affects responses to vagus nerve stimulation, finding it influences pupillary responses and cortical activity alignment with noradrenergic projections.
Helena Casademunt, Hongruo Zhang, John Laver…·Aravinthan D.T. Samuel
The paper analyzes brain-wide neural activity in C. elegans during olfactory navigation and identifies functional circuits linking sensory input to motor behavior across different environments and behavioral states.
Jared Luchetta, Gianna M DeMarco, Anduela Thaqi…·Abbie C Chapman
This study shows chronic hypertension increases BBB permeability and anxiety-like behaviors in female rats but not males in a vascular cognitive impairment model.
Christopher John Parker, Nicholas M Timme
The paper analyzes the dynamics of a whole-mouse-brain neural mass model coupled via an empirical connectome, finding chaotic oscillations and suppression of chaos with network modifications.
Serhii Bahdasariants, Sergiy Yakovenko
This paper introduces a phase decoder that reconstructs missing muscle activity from sparse EMG signals, achieving accurate phase estimation and muscle activation reconstruction in real-time.
Liesbeth Voorbraeck, Jesus Alarcon-Gil, Mite Mijalkov…·Luana Naia
This study shows that mitovesicles from Alzheimer's disease mouse models undergo stage-specific proteomic changes that reflect mitochondrial dysfunction and provide a conserved disease signature in humans.
Kehan Lu, Tianhao Chu, AIERSI TUERHONG…·SI WU
This study shows that oscillatory phase coding emerges in adaptive RNNs during sequence working memory tasks, with phase encoding serial order and amplitude encoding item identity.
Francisco Fuentealba-Villarroel, Leonardo M Bastos, Matheus Gallas-Lopes…·Angelo Piato
This study shows UCS in zebrafish alters exploratory behavior patterns, with method-dependent identification of resilient-like archetypes.
Dongqi Zhang, Magdalena Matic, Airi Tarutani…·Sjors Scheres
The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.
Dulaj Dasanayake, Sumonta Nandy Amit, Bramsh Qamar Chandio
BundleMorphometry quantifies local white matter bundle shape using nonlinear registration, revealing deformation patterns in glioma and Parkinson's disease datasets.
Antonela Bonafina, Anais Boutsen, Haw-Yuan Cheng…·Laurent Nguyen
This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.
Chieh Yu, Lenae Joe, Anthony Newman, Jon-Paul Pepper
This study establishes a chronic motor nerve transection model in rats and characterizes distinct pathological changes in proximal and distal nerve stumps.
Kasper Smeets, Shuqi Wang, Valentin Schmutz, Wulfram Gerstner
This paper shows that heterogeneous spiking networks can produce fast rate-based dynamics without assuming Poisson spikes or slow dynamics.
Path knockout identifies dominant multi-synaptic pathways in connectomes by quantifying the impact of neuron removal on connection strength, outperforming existing methods in Drosophila circuits.
Xin Jia, Cuidie Zeng, Linchen Liu…·Fangxiao Cheng
This study shows that myelin affects hippocampal network function by shaping extracellular space, not only by insulating axons, with demyelination altering diffusion, flow, and synaptic transmission.
Oliwia Górska, Limor Freifeld, Kristen E Severi
This study develops an assay in larval zebrafish to investigate visual desensitization and its role in synaptic plasticity by measuring escape responses to varying visual stimuli.