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This study shows metformin reduces HA and IL-6 production in TED orbital fibroblasts by activating AMPK and counteracting PDGF signaling.

This study evaluates dogs as sentinels for Rift Valley fever virus surveillance in Madagascar, finding proportional relationships between force of infection in dogs, humans, and cattle.

This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.

This paper introduces an optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system, showing improved staining consistency and LCS detection across species.

The paper develops a DNA-based qPCR assay to quantify disease responses of two pennycress accessions to Alternaria japonica and Sclerotinia sclerotiorum, showing accession 2032 is more susceptible than MN106.

This paper introduces a novel genetic mouse model of aortic dissection showing immune cell infiltration and altered ECM dynamics.

This study shows that smooth-muscle calcineurin, independent of its phosphatase activity, drives a gene expression program that causes hypertension.

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.

This study examines how RAGE signaling and Type 2 Diabetes affect cortical bone mechanics, structure, and material properties in mice, showing sex-specific improvements with RAGE ablation.

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

The paper uses volumetric imaging and single-cell RNAseq to study human dental pulp responses during tooth decay, identifying cellular mechanisms and progression stages.

This study tracks liver disease progression in PEX1-G844D mice, identifying peroxisomal dysfunction and metabolic changes that contribute to hepatosteatosis, inflammation, fibrosis, and cancer.

The paper identifies 2,3-linked sialic acids in the mammary glands of pregnant dairy heifers, suggesting susceptibility to H5N1 influenza virus infection.

This study identifies two distinct cell proliferation populations during liver regeneration in mice with acute liver injury using single-cell RNA-seq.

This study identifies TRPV4 as a cellular stiffness sensor linking matrix stiffness and atherosclerosis using human tissues and a mouse model.

Across nine Kenyan counties, Stomoxys flies fed on 15 vertebrate hosts, carried Anaplasma, Theileria/Babesia and Trypanosoma DNA, and transmitted T. vivax, T. evansi and Theileria mutans to mice.

This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.

This study shows that bone pain in Fibrous dysplasia is intrinsic and not caused by abnormal sensory nerve sprouting or neuroma formation.

This study shows that Alzheimer's disease mice exhibit age-dependent, odorant-specific changes in olfactory sensitivity, with hyperosmia to esters at 2 months and hyposmia at 4 months.

This study shows LOX promotes actin-dependent neutrophil activation and cytotoxicity in diabetes, contributing to diabetic retinopathy through F-actin remodeling and granule clustering.