PathologyAlzheimer s Research & TherapyPeer-reviewed
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study
Elaheh Salardini, Ryan S. O’Dell, Em Tchorz…·Adam P. Mecca
This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.