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This study analyzes lifespan differences between male and female Alzheimer's disease mouse models, finding significant sex-based survival variations in two AD models.

This study shows that high dietary calcium intake in late gestation does not disrupt maternal calcium homeostasis in dairy sheep and goats but reduces offspring weight gain.

This study shows that increased step length variability during walking raises metabolic cost by 0.7% per 1% increase in variability.

This study identifies and characterizes vitellogenin receptors in Mugil cephalus using orthology, domain analysis, and structural modeling, revealing their evolutionary conservation and functional relevance in reproduction.

This study shows chronic Bt spore ingestion in Drosophila reduces lifespan, causes gut inflammation, and promotes aging.

This study examines how endurance exercise with reduced muscle glycogen affects substrate utilization and signaling in human muscle fibers, finding altered fatty acid metabolism and mTORC1-autophagy dynamics.

This study shows that inhibiting mitochondrial fission with mdivi-1 reduces thoracic aortic aneurysm (TAA) progression in mice by limiting vascular remodeling and inflammation.

This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.

This study shows that deleting Nudt19 in mice on a high fat diet increases albuminuria and alters kidney lipid metabolism.

This paper develops a method to efficiently transduce pancreas tissue slices with CaMPARI2 for analyzing calcium responses, finding size-dependent differences in glucose-induced activity between isolated and slice-islets.

This paper demonstrates that azo-HU308, a light-activatable cannabinoid, optically controls Ca2+ influx in pancreatic β-cells via TRPC channels, not CB2 receptors.

This study measures blood biomarkers of neurodegeneration and inflammation in rhesus macaques across adulthood, finding age-related increases in NfL and IL-6 and a decline in Aβ42/Aβ40 ratio.

This study shows that CTIP and biophysical models overpredict heat risk, as healthy adults maintained heat balance across extreme heat conditions.

This study identifies altered placental morphology and metabolomic profiles in metabolically healthy obese pregnancies, highlighting unique metabolic pathways and potential biomarkers.

This study investigates corneal wound healing using multi-omics analyses, identifying molecular factors and epithelial plasticity mechanisms critical for tissue regeneration.

This study examines variability in polyphenol metabolite production after a controlled dietary challenge and finds significant individual differences and low agreement between tertiles of metabolite output.

This study compares electrophysiological properties of left and right stellate ganglia neurons in mice, finding differences in resting membrane potential and minimum diastolic potential between sexes and ganglia, but similar action potential characteristics overall.

This study shows that ERG1A overexpression in C2C12 myotubes reduces calsequestrin1 levels, leading to increased intracellular calcium concentration through modulation of calcium buffering.

This study finds that male elite endurance athletes have greater lipid droplet-mitochondria contact in skeletal muscle compared to recreationally active individuals, linked to higher organelle densities and specific size-related associations.