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Historical contingency is revealed by trade-offs upon sequential adaptation to different infection routes

This study shows that past adaptation to systemic infection affects the speed and mechanism of adaptation to oral infection in Drosophila, with sex-specific outcomes and trade-offs.

A Minimal Synthetic Cleavage Module Enables Selective Degradation of Pathogenic r(CUG) Repeats in Cells

This study develops a synthetic cleavage module that selectively degrades pathogenic r(CUG) repeats in cells, reducing DM1-associated pathology without DNA damage.

Ribosomal Remodeling and Translational Suppression in the Post-Arrest Heart

This study investigates how cardiac arrest affects myocardial ribosome biology and protein synthesis in pigs and mice, finding increased ribosomal transcripts with ischemic burden and suppressed ribosome activity post-arrest.

A multipotent mouse distal airway secretory cell population that contributes to both airway and alveolar regeneration

This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

Application of metagenomic sequencing to improve sessile serrated lesion detection using the faecal immunochemical test

This study investigates whether FIT samples can reveal a microbial signature of sessile serrated lesions, finding no significant differences in community structure but suggesting potential functional differences.

Breaking the bottleneck: semi-automated quantification of actin filament dynamics

The paper introduces SMAUG, a semi-automated tool for analyzing actin filament dynamics from TIRF microscopy images, reducing analysis time while maintaining accuracy.

Preferential Isoform Usage and Isoform Switching in Systemic Lupus Erythematosus Patients with Distinct Autoantibody Profile

The paper identifies subgroup-specific isoform usage and switching in SLE patients with distinct autoantibody profiles, highlighting their functional relevance in autoimmune pathogenesis.

Reinforcement sculpts synaptic ensembles for operant dendritic control

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

scCont: Interpretable Contrastive Learning for Functional Characterization of Cellular State Transitions

scCont is an unsupervised contrastive learning framework that extracts interpretable functional transition units from scRNA-seq data, outperforming baseline methods in capturing biologically meaningful dynamics.

Lineage-specific histories rather than shared drivers shape olfactory evolution in New World monkeys

The paper investigates olfactory receptor repertoire variation in New World monkeys, finding that lineage-specific histories, not shared ecological drivers, shape olfactory evolution.

Examining urban weed response to elevated salt levels

This study examines urban weed response to elevated salt levels through garden experiments, finding some support for salt tolerance adaptation but highlighting environmental heterogeneity and plant variability.

Sex-dependent and region-specific morphological adaptations in astrocytes following early-life stress

This study uses sparse eGFP labeling to compare astrocyte morphology across brain regions and sexes in mice, finding sex-dependent and region-specific changes after early-life stress.

Structural Variant Aware Identity-by-Descent Detection on Pangenome Graphs

GIBD detects IBD segments in pangenome graphs and annotates them with structural variants, outperforming existing methods in accuracy and speed.

Early AAV9-mediated SLC9A6 gene replacement preserves cerebellar structure and motor function in the shaker rat model of Christianson syndrome

This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.

Virtual dynamics of spatiotemporal single-cell interactions

CytoBridge reconstructs continuous virtual cell dynamics from sparse spatial transcriptomic data across development, regeneration, and neurodegeneration.

Genomic analysis of the Streptococcus anginosus group; taxonomic implications, evolutionary insights and clinical considerations

This study uses genomic analysis to reclassify the Streptococcus anginosus group into four taxa, revealing diversity and lineage-associated traits linked to invasive disease.

Establishing an ex vivo platform for molecular profiling of skin structural cells using frozen human skin biopsies

This study establishes a scalable ex vivo platform using frozen human skin biopsies to study inflammatory responses in skin structural cells.

The enemy of my enemy: A bacterial antagonist rescues Chlamydomonas by inactivating a toxin from a rival

The paper shows that Pseudomonas fluorescens protects Chlamydomonas reinhardtii from Pseudomonas protegens by inactivating its toxin protegencin in a tripartite microbial interaction.

Somatic structural variation discovery on cancer pangenome graphs

JANUS discovers somatic structural variants in cancer genomes using a pangenome graph approach, achieving high accuracy and efficiency compared to traditional methods.

UVC Irradiation Induces Time-Dependent Proteomic Remodeling in Geodermatophilus obscurus G20

This study examines proteomic changes in Geodermatophilus obscurus G20 under UV stress, showing distinct responses in acute and recovery phases.