Discover, rate, and discuss biology preprints.

The paper quantifies how species diversity affects irreducible dynamical heterogeneity in ecological communities near equilibrium.

This study evaluates synthetic graph generators for rabies transmission modeling, finding that the degree-corrected stochastic block model best reproduces empirical contact networks and outbreak dynamics for short-infectious-window pathogens.

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

This study shows that features of mitochondrial ribosomes, such as host protein acquisition and structural changes, are also present in an ancient insect endosymbiont, suggesting these traits arise from endosymbiont ancestry rather than mitochondrial specificity.

This study shows that Gnpat-knockout mice exhibit testicular interstitial remodeling and germ-cell loss due to ether-lipid deficiency, with no DNA-damage checkpoint activation.

The paper identifies recurring brain states across tasks and links their dynamics to trial-to-trial performance and individual response strategies.

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

The paper shows that human endothelial cells respond to sustained sub-threshold acoustic stimulation with delayed activation, unlike immediate responses to over-threshold mechanical stimulation.

The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.

The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.

This study compares dual-enzyme spore display with mixed single-enzyme spores for cellulose hydrolysis, finding that mixing single-enzyme spores yields higher glucose production.

This paper develops a synthetic VEEV reporter virus for high-throughput antiviral screening, identifying inhibitors of VEEV replication using FDA-approved compounds.

This study shows that repeated pup exposure converts virgin male mice to a parental state via calcitonin receptor-expressing neurons in the medial preoptic area.

The paper examines sex differences in gene expression and alternative splicing in stick insects, finding that splicing variation declines more rapidly than gene expression after the transition to asexuality.

This paper describes two novel Corynebacterium species isolated from human nasal passages and skin, along with characteristics of two strains of a recently named species.

This study shows that neurons in primate frontal cortex encode both object locations and their spatial relationships during working memory.

This study identifies STING as a therapeutic target for Kawasaki disease by analyzing spatial immune architecture in cardiac inflammation.

This study shows WRN deficiency causes oncogenic rearrangements at TA-rich tandem repeats by destabilizing them, leading to chromosomal breaks and activation of TERT in melanoma.

The paper develops an agent-based model of breast cancer metastases to predict responses to dual checkpoint inhibition and identifies spatially-informed treatment strategies.