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Long-read assemblies of an inbred cannabis trio plus whole-genome sequencing of 40 cultivars link cannabinoid synthase gene deletions to chemotype and associate CsTLP1 loss with powdery mildew susceptibility.

Among dozens of ImageNet-trained networks scored against macaque V4/IT recordings and human behavior, DenseNet-169, CORnet-S and ResNet-101 rank highest, and brain similarity stops tracking accuracy above 70% top-1.

Hybrid polisher that leaves solid-k-mer-supported contig regions untouched gave HG002 long-read assemblies fewer errors than Racon in under one-third the time and about half the memory.

Updated pipeline and genetic data confirm genetically supported drug targets succeed more often; Mendelian (OMIM) support replicates prospectively, while GWAS support is weaker unless coding-linked.

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

Mutect2 calls somatic SNVs and indels via local haplotype assembly, Bayesian genotyping and F-score-optimised filtering, with roughly one false call per 5 Mb in exome replicate-versus-replicate tests.

StringTie2 assembles error-prone long reads, recovering on average 8.3 and 2.6 times as many correct transcripts as FLAIR and Traphlor, and outperforms Scallop on short reads.

Profiling 2,925 plasma proteins in 4,331 people aged 18-95 reveals non-linear aging: protein waves crest at 34, 60 and 78 years, later waves overlapping disease proteomes.

Kraken 2's minimizer-keyed compact hash table cuts memory 85% versus Kraken 1 and classifies over 5 times faster with comparable accuracy; translated search boosts viral sensitivity.

Kappa, an open-source Fiji plugin, fits user-clicked cubic B-splines to image pixels to measure curvature; on synthetic sine waves, Pearson r ≃ 0.95 at signal-to-noise above 15 dB.

Neural-network ensembles scoring 69 peak features, plus fragment interference subtraction, boost data-independent acquisition (DIA) proteomics identifications and quantification precision, especially with short chromatographic gradients.

Harmony alternates diversity-penalized soft clustering with cluster-specific linear correction of PCA embeddings, integrating single-cell datasets over multiple covariates and handling 500,000 cells in 7.2GB of memory.

OrthoFinder now infers orthogroups, rooted gene and species trees, duplications and orthologs from proteomes alone, topping Quest for Orthologs accuracy tests while rivaling heuristic tools' speed.

Across 37,688 Parkinson's cases, 18,618 proxy-cases and 1.4M controls, 90 risk signals map to 78 loci (37 new); an 1805-variant polygenic score explains 26-36% of heritability.

Signaling Pathways Project maps over 10,000 transcriptomic and ChIP-Seq experiments to signaling nodes and ranks node targets by meta-analysis (consensomes), validated against literature and bench assays.

GTEx v8 maps expression and splicing QTLs in 49 tissues from 838 donors: cis-eQTLs cover 94.7% of protein-coding genes, and cross-tissue QTL sharing mirrors cell-type composition.

Galaxy-based platform builds UCSC Assembly Hubs, JBrowse and Apollo annotation browsers without bioinformatics expertise; parasitoid wasp browsers supported undergraduate research courses producing 192 gene models.

Permutation-based maximal matched-pairs symmetry tests show 40.8% of 3,572 partitions from 35 published phylogenetic datasets reject stationary, reversible, homogeneous evolution, frequently altering inferred tree topologies.

A PacBio and Hi-C tomato genome rebuild shrinks gaps from 81.71Mb to 44Kb; the matching ITAG4.0 annotation adds 4,794 genes and updates most carried-over models.

MRtrix3 provides an open-source C++11 and Python software framework, command-line suite, and OpenGL 3.3 viewer for fast multi-dimensional medical image processing and diffusion MRI analysis.