Tianyuan Wang

This study maps the epigenomic landscape of human myometrium at term pregnancy, identifying enhancers and regulatory elements associated with PGR and PLCL2.

The paper investigates the effects of mineralocorticoid receptor knockout on CA2 neurons, finding they adopt a CA1-like molecular and morphological phenotype.

WUREN is a multimodal model that fuses sequence, graph, and structural features to predict protein interaction interfaces and antigen epitopes, achieving state-of-the-art performance.

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

This study shows that a brain-specific PGC1α isoform mutation causes motor deficits and gene upregulation in female mice, suggesting a role in female-specific transcriptional programs.

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.

This study shows that mitochondrial acetyl-CoA reversibly modulates histone acetylation and gene expression in models of mtDNA depletion.

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.