Discover, rate, and verify biology preprints.

Pre-existing genome architecture partitions viral takeover in the smallest free-living eukaryote

The paper tracks viral infection in Ostreococcus tauri, showing pre-existing genome architecture dictates viral positioning and transcriptional changes during infection.

Novel regulators of zebrafish glomerular development

The paper identifies eight new genes involved in zebrafish glomerular development through transcriptome analysis and CRISPR-Cas9 screening, linking them to proteinuria and glomerular leakage.

H5N5 virus transmission is driven by repeated cross-Atlantic introductions and transmission among high latitude seabirds

This study shows H5N5 viruses have been repeatedly introduced across the Atlantic by high latitude seabirds, with more frequent introductions in fall and spring, and a distinct ecology from H5N1.

Genomic Correlates of APOBEC-Associated Mutagenesis in Esophageal Squamous Cell Carcinoma

This study identifies genomic correlates of APOBEC-associated mutagenesis in ESCC, finding that SBS18 shows the most consistent inverse association, while ZNF750 mutations are linked to higher APOBEC burden.

Small molecule structure elucidation from NMR spectra with generative and reasoning models

This paper introduces an AI system for automated small molecule structure elucidation from NMR spectra, combining generative models with reasoning agents to outperform existing tools.

Reconstructing human gene regulatory evolution using deep learning

This study uses deep learning to predict cis-regulatory effects of human-specific mutations across 305 tissues, revealing their role in gene expression evolution.

Behavioral divergence across replicated predation regimes is species-specific in two sympatric poeciliid fishes

The paper compares behavioral and cognitive responses to predation regimes in two sympatric fish species, finding species-specific divergence despite shared environmental conditions.

DGM Is Dead; Long Live DGM-Star! A Quantization-Theoretic Approach to Gamma Rate Discretization

The paper introduces a new method to discretize Gamma rate distributions in phylogenetics, reducing branch length bias compared to the standard DGM.

EpiRank: partner-agnostic surface-patch retrieval for epitope prediction of protein binding interfaces

EpiRank evaluates epitope prediction by ranking surface patches on single-chain geometry, finding it correctly identifies real epitopes 64% of the time but with significant baseline overlap.

Single-cell foundation models transfer across deep evolutionary distances

This paper evaluates the transferability of single-cell foundation models across deep evolutionary distances using developmental atlases of Dictyostelium discoideum and Caenorhabditis elegans.

SF3b inhibitors suppress proliferation of nonsmall cell lung cancer cells irrespective of EGFR mutation status

The paper tests SF3b inhibitors on NSCLC cells with different EGFR statuses, finding growth suppression regardless of EGFR mutation, suggesting a mechanism independent of EGFR kinase activity.

Structural Evolution of Neural Networks during Zebrafish Early Development

The paper uses live-cell imaging to study neural network development in zebrafish, revealing conserved structural dynamics and optimization strategies.

Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations

The paper uses Neanderthal ancestry patterns to identify genomic regions enriched with recessive deleterious mutations using a machine learning classifier.

Genomic forecasting links climate-associated variation to spring phenology in the European wild apple, a crop wild relative of the cultivated apple

The paper tests if climate-associated genomic variation predicts phenotypic adaptation in European wild apple, finding genomic offsets link to bud-break timing but not other traits.

Variational quantum thermalization of environment-coupled DNA sequence biases

The paper uses variational quantum simulation to model DNA sequence biases under thermal environments, showing both classical and quantum methods enhance target sequence probabilities.

Computation or Weight Adaptation? Rethinking the Role of Plasticity in Learning

This paper challenges the traditional view that neural plasticity is essential for adaptive learning by showing that sufficiently trained large language models can achieve adaptability through computation alone.

A centromere but not just a centromere: structure and evolution of a selfish chromosomal supergene in monkeyflowers

The paper analyzes the structure and evolution of a selfish centromere in monkeyflowers, identifying genomic expansions and gene content differences that may contribute to meiotic drive.

HERC1 Loss of Function Causes a Developmental Disorder with Impaired Hippocampal Function

This study shows that HERC1 loss causes neurodevelopmental abnormalities in mice, including hippocampal dysfunction and sex-dependent synaptic defects.

Hippocampal-somatomotor coactivation and perceived benefit following Mindfulness-Based Cognitive Therapy for Life in healthcare students: An exploratory randomized study

This study examines if MBCT-L affects hippocampal-somatomotor coactivation in healthcare students, finding no significant group-time interaction but associations between coactivity and perceived benefits.

Cartilage canals in sharks and rays show that blood vessels can exist in mature cartilage without triggering endochondral bone formation

This study shows that sharks and rays have cartilage canals in their adult skeletons, which are vascular but do not trigger endochondral bone formation, suggesting an ancient role in nutrient transport.