Author

Celeste Nobrega

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:zebrafish· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Filippo BirocchiiD· 2 shared Joel H. GraberiD· 2 shared John G. DoenchiD· 2 shared Kathleen B. YatesiD· 2 shared Marcela Valderrama MausiD· 2 shared Robert T. MangusoiD· 2 shared Aidan Cruickshank· 1 shared Alexander ArmstrongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Filippo BirocchiORCID

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Author profile →

4 papers

Recent·Most cited

Novel regulators of zebrafish glomerular development

Omodasola Adekeye, Blanca de Juan Mora, Ritu Tomar, Olaleye Olijuyin, Clémence Rouzier, Brian Hartman, Nicole Rainford, Daemon Dikemon, Celeste Nobrega, Joel H. Graber, Caramai Kamei, Iain A. S. Drummond

The paper identifies eight new genes involved in zebrafish glomerular development through transcriptome analysis and CRISPR-Cas9 screening, linking them to proteinuria and glomerular leakage.

bioRxiv · Oct 31, 2026 · PreprintDevelopmental Biology

Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation in Nothobranchius furzeri.

Sonia Sandhi, Hannah M. Somers, Matthew Cox, Celeste Nobrega, Ryan P. Seaman, Elizabeth Bakers, Olivia Letchner, Robyn E. Reeve, Romain Menard, James W. Godwin, Anastasia Paulmann, Aric N. Rogers, Dario Riccardo Valenzano, Joel H. Graber, Hermann G. Haller, Romain Madelaine

This study shows that intermittent fasting improves muscle health and extends lifespan in both sexes of African turquoise killifish, with sex-specific molecular and cellular changes.

bioRxiv · Feb 11, 2026 · PreprintPhysiology

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Nelson H. Knudsen, Giulia Escobar, Felix Korell, Tamina Kienka, Celeste Nobrega, Seth Anderson, Andrew Y. Cheng, Maria Zschummel, Alexander Armstrong, Amanda A. Bouffard, Michael C. Kann, Sadie Goncalves, Hans W. Pope, Mitra Pezeshki, Alexánder Rojas, , Marcela Valderrama Maus

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

Nature · Sep 24, 2025Peer-reviewedImmunology

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Celeste Nobrega, Jonathan Perera, Ewa Wrona, Margaret Hu, Yunkang Lin, David Wei Wu, Maria Saberi, Ilario Scapozza, Aidan Cruickshank, Elliot C. Woods, , Robert T. Manguso

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

bioRxiv · May 5, 2025 · PreprintCancer Biology