Developmental BiologyNucleic Acids ResearchPeer-reviewed
Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation
Courtney W. Hanna, Jiahao Huang, Christian Belton…·Gavin Kelsey
This study shows that loss of SETD1B in oocytes causes redistribution of H3K4me3, with loss at active promoters and gain at CpG-rich regions, revealing distinct roles for SETD1B and MLL2 in epigenetic regulation.