Cancer BiologybioRxivPreprint
Acquired secondary HER2 mutations enhance HER2/MAPK signaling and promote resistance to HER2 kinase inhibition in HER2-mutant breast cancer
A. Marin, A. A. Mamun, H. Akamatsu…·A. B. Hanker
This study identifies secondary HER2 mutations that confer resistance to HER2 kinase inhibitors in HER2-mutant breast cancer by enhancing HER2 signaling and reducing drug binding.
DOI 10.1101/2022.09.23.509246