Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritis
A. J. Knights, E. C. Farrell, O. M. Ellis, L. Lammlin, L. M. Junginger, P. M. Rzeczycki, R. F. Bergman, R. Pervez, M. Cruz, A. A. Samani, C.-L. Wu, K. D. Hankenson, T. Maerz
This study identifies distinct synovial fibroblast subsets in PTOA and shows that Prg4hi fibroblasts secrete Rspo2 to drive pathological crosstalk.
bioRxiv · May 6, 2022 · PreprintCell Biology