A. Kaur

Identification of ABHD6 as a regulator of lysophosphatidylserines in the mammalian liver and kidneys

The paper identifies ABHD6 as a lyso-PS lipase in the liver and kidneys, validating its enzymatic activity in vitro and in vivo.

Diversification of an emerging bacterial plant pathogen; insights from the global spread of Xanthomonas euvesicatoria pv. perforans

This study analyzes the global genetic diversity and evolution of Xanthomonas euvesicatoria pv. perforans, revealing population structure and effector gene variation linked to its spread as a tomato pathogen.

Within-host adaptation of a foliar pathogen, Xanthomonas, on pepper in presence of quantitative resistance and ozone stress

This study examines how elevated ozone stress affects the eco-evolutionary dynamics of Xanthomonas perforans on resistant and susceptible pepper cultivars, revealing increased disease severity and pathogen population heterogeneity.

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

Conformational Dynamics and metal-ion interactions in human small Ubiquitin-like modifier (SUMO2)

This study investigates Cu2+ ion binding and conformational flexibility in SUMO2, showing its impact on aggregation and non-covalent interactions with SIMs.

Comprehensive Codon Usage Analysis Across Diverse Plant Lineages

This study analyzes codon usage patterns across plant lineages, finding that vascularization influences codon usage more than seed production and identifying dinucleotide biases across species.

Lysosomal Degradation Pathways Target Mutant Calreticulin and the Thrombopoietin Receptor in Myeloproliferative Neoplasms

This study shows that mutant calreticulin induces lysosomal degradation of the thrombopoietin receptor in MPNs, and drug-induced lysosomal activation reduces mutant protein levels and pathogenic effects.

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

This study investigates maternal cytomegalovirus (CMV) antibody responses and viral load in rhesus macaques to determine their association with vertical transmission risk, finding no link between plasma viremia or humoral responses and congenital CMV in immunocompetent dams.

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

This study shows that pre-existing CMV immunity in nonhuman primates reduces placental transmission and fetal loss during reinfection compared to primary infection.

A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing

The paper compares HLA-B44 peptidomes with and without tapasin to show tapasin influences C-terminal tryptophan residues and peptide binding affinity.

Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis

The paper identifies two bacteria capable of degrading levoglucosan and analyzes their genome and proteome to understand the degradation pathway and related enzymes.

SMRT-AgRenSeq-d in potato (Solanum tuberosum) identifies candidates for the nematode resistance Gpa5

The paper introduces SMRT-AgRenSeq-d, a method for identifying NLR resistance genes in potato, and applies it to find nine strong candidates for the nematode resistance gene Gpa5.

Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models

This study identifies a triplet therapy combining AKT, PDK1-4 inhibition, and PP2A reactivation that effectively eradicates brain tumor models by overcoming kinase inhibitor tolerance through combinatorial effects on signaling rewiring, OXPHOS, and apoptosis.

Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation

The paper identifies a rare invasive subpopulation of melanoma cells that drives metastasis, independent of environment, through non-genetic gene expression fluctuations.

Mathematical Modeling of Rhesus Cytomegalovirus (RhCMV) Placental Transmission in Seronegative Rhesus Macaques

The paper develops a mathematical model of RhCMV placental transmission in rhesus macaques to study factors affecting congenital CMV infection risk.

PME-1 suppresses anoikis, and is associated with therapy relapse of PTEN-deficient prostate cancers

This study identifies PME-1 as a biomarker for aggressive PTEN-deficient prostate cancers by showing its role in suppressing anoikis.

Xanthomonas indica sp. nov., a non-pathogenic bacterium isolated from healthy rice (Oryza sativa) seeds from India

The paper describes the discovery and characterization of a new non-pathogenic Xanthomonas species, Xanthomonas indica, isolated from healthy rice seeds.

clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ

clampFISH 2.0 enables rapid, scalable detection of multiple RNA species in single cells and tissue sections by improving signal amplification and reducing time and cost.

Development of Actionable Targets of Multi-kinase Inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells

The paper develops a platform to identify kinase targets of multi-kinase inhibitors in glioblastoma cells and finds AKT, PDK1, and PDK4 as targets of staurosporine derivatives that synergize with PP2A reactivation.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway

The paper reports genome sequences of two gram-positive Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway to metabolize sulfoquinovose, producing sulfolactate as the end-product.

A bacterial derived plant- mimicking cytokinin hormone regulates social behaviour in a rice pathogen

This study identifies a bacterial cytokinin hormone produced by Xoo that regulates planktonic lifestyle and virulence in rice pathogens.

Adjuvant and immunomodulatory potential of Natural Killer T (NKT) activation by NKTT320

This study evaluates the adjuvant and immunomodulatory effects of NKTT320, a humanized monoclonal antibody that activates iNKT cells, showing enhanced immune responses and inflammation resolution.

Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptor

The paper uses whole-cell imaging to reveal a calcium-APPL1-dynein mechanism that directs EGFR trafficking to the peri-nuclear region.

Global transcriptome analysis of Stenotrophomonas maltophilia in response to growth at human body temperature

This study identifies temperature-regulated genes in Stenotrophomonas maltophilia using transcriptome analysis, revealing adaptations for human body temperature.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

Discerning role of a functional arsenic resistance cassette in evolution and adaptation of a rice pathogen

The paper investigates an arsenic resistance mechanism in a rice pathogen, revealing a horizontally acquired resistance cassette that enhances survival in arsenic-rich environments.

ThermoBRET: a ligand-engagement nanoscale thermostability assay applied to GPCRs

ThermoBRET quantifies GPCR thermostability using BRET without labelled ligands, revealing ligand effects on protein unfolding in non-purified samples.