Cancer BiologybioRxivPreprint
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
J. A. Johannessen, M. Formica, N. R. Brathen…·H. Knaevelsrud
This study uses a Drosophila model to show that MLL-AF4 promotes hematopoietic hyperplasia and that DOT1L inhibition can reverse the leukemia-like phenotype.
DOI 10.1101/2022.11.08.515565