TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors
G. Cossu, F. Galli, U. Roostalu, B. M. Aldeiri, T. Miyake, A. Albertini, L. Bragg, S. Prehar, J. McDermott, E. Cartwright
This paper demonstrates that TNAP negatively regulates TGF-β signaling by dephosphorylating SMAD2/3, thereby limiting cardiac and skeletal muscle fibrosis.
bioRxiv · May 30, 2019Cell Biology