T. Miyake

Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection

This study shows HSV-1 UL12.5 promotes reactivation by inducing mitochondrial nucleic acid sensing, which activates innate immune pathways and supports lytic gene expression during latency exit.

The differential effect of optogenetic serotonergic manipulation on sustained motor actions and stationary waiting for future rewards in mice

This study investigates how optogenetic manipulation of DRN serotonergic neurons affects motor actions and waiting behavior in mice during reward tasks, finding distinct effects on sustained actions versus stationary waiting.

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

This study elucidates the mechanism of intramembrane proteolysis by E. coli RseP through crystal structures and mutational analysis, revealing a gating mechanism for substrate entry.

Moving toward generalizable NZ-1 labeling for 3D structure determination with optimized epitope tag insertion

The paper improves epitope tag insertion for 3D structure determination by using PA14 tags, which reduce structural changes in targets compared to PA12 tags.

Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of NP interacting with VP35

This study identifies two NP domains controlling Ebola virus inclusion body formation and RNA synthesis, with the central domain interacting with VP35 to regulate these processes.

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors

This paper demonstrates that TNAP negatively regulates TGF-β signaling by dephosphorylating SMAD2/3, thereby limiting cardiac and skeletal muscle fibrosis.