Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel
Y. Wang, S. Olieslagers, A. B. Johnsen, S. Mastitskaya, H. Ni, Y. Zhang, N. Black, C. Anderson, C. Cox, A. Bucchi, S. Wegner, B. Bano-Otalora, C. Petit, E. Gill, S. J. Logantha, , A. DSouza
The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.
bioRxiv · Jun 27, 2019Physiology