Author

A. Aman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Dong· 2 shared C. A. Zepeda-Velazquez· 2 shared M. Schapira· 2 shared R. Al-awar· 2 shared T. Kiyota· 2 shared A. Mamai· 1 shared C. Arrowsmith· 1 shared C. H. Arrowsmith· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

A. Dong

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Author profile →

2 papers

Recent·Most cited

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

S. Perveen, C. A. Zepeda-Velazquez, D. McLeod, R. Marcellus, M. Mohammed, M. Abbey, D. Ensan, D. Panagopoulos, V. Trush, E. Gibson, A. Dong, L. Halabelian, G. Poda, J. Owen, A. Aman, , M. Vedadi

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

bioRxiv · Jan 5, 2022 · PreprintBiochemistry

Structure Activity Relationship of USP5 Allosteric Inhibitors

M. K. Mann, C. A. Zepeda-Velazquez, H. G. Alvarez, A. Dong, T. Kiyota, A. Aman, C. Arrowsmith, R. Al-Awar, R. J. Harding, M. Schapira

This paper develops a chemical series of USP5 allosteric inhibitors, identifies a selective compound with structural and functional characterization.

bioRxiv · May 17, 2021 · PreprintBiochemistry