Author

J. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Aman· 1 shared A. Dong· 1 shared A. L. Harris· 1 shared A. Mamai· 1 shared A. Miar· 1 shared B. Markelc· 1 shared C. A. Zepeda-Velazquez· 1 shared C. Gillett· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Aman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

S. Perveen, C. A. Zepeda-Velazquez, D. McLeod, R. Marcellus, M. Mohammed, M. Abbey, D. Ensan, D. Panagopoulos, V. Trush, E. Gibson, A. Dong, L. Halabelian, G. Poda, J. Owen, A. Aman, , M. Vedadi

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

bioRxiv · Jan 5, 2022 · PreprintBiochemistry

Superinfection Exclusion of Alphaherpesviruses Interferes with Virion Trafficking

M. P. Taylor, J. P. Cwick, J. Owen, I. Kotchetkova, N. V. Horssen

This study investigates gD-independent superinfection exclusion in alphaherpesviruses, showing PRV and HSV-1 use distinct mechanisms to restrict co-infection.

bioRxiv · Dec 16, 2021Microbiology

Cancer-associated hypersialylated MUC1 drives the differentiation of monocytes into macrophages with a pathogenic phenotype

R. Beatson, R. Graham, F. Grundland Freile, D. Cozzetto, S. Kannambath, E. Pfeifer, N. Woodman, J. Owen, R. Nuamah, U. Mandel, S. Pinder, C. Gillett, T. Noll, I. Bouybayoune, J. Taylor-Papadimitriou, J. M. Burchell

This study identifies MUC1-ST as a driver of monocyte differentiation into pathogenic macrophages in the tumor microenvironment, associated with poor breast cancer prognosis.

bioRxiv · May 6, 2020Cancer Biology

Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids

P. Kannan, M. Paczkowski, A. Miar, J. Owen, W. W. Kretzschmar, S. Lucotti, J. Kaeppler, J. Chen, B. Markelc, L. A. Kunz-Schughart, A. L. Harris, M. Partridge, H. Byrne

This study shows radiation-resistant prostate cancer cells enhance survival and resistance of sensitive cells in spheroids through competitive and antagonistic interactions.

bioRxiv · Mar 3, 2019 · PreprintCancer Biology