Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
M. K. Mann, E. Z. WOLF, M. Silva…·M. Schapira
The paper identifies a small molecule ligand for the ZnF-UBD of USP3 with a KD of 14 µM, which could serve as a starting point for developing DUBTACs.
R. J. Harding, I. Franzoni, M. K. Mann…·C. H. Arrowsmith
The paper identifies and characterizes a chemical probe, SGC-UBD253, that targets the HDAC6 UBD with selectivity, and a less active derivative as a negative control.
M. G. Alteen, J. C. Deme, C. P. Alvarez…·R. J. Harding
This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.
M. K. Mann, C. A. Zepeda-Velazquez, H. G. Alvarez…·M. Schapira
This paper develops a chemical series of USP5 allosteric inhibitors, identifies a selective compound with structural and functional characterization.
R. J. Harding, J. C. Deme, J. F. Hevler…·C. H. Arrowsmith
This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.
M. K. Mann, I. Franzoni, R. Ferreira de Freitas…·M. Schapira
The paper identifies small molecule antagonists targeting the USP5 ZnF-UBD, providing a framework for developing chemical probes to study its role in ubiquitin signaling.
R. J. Harding, P. Loppnau, S. Ackloo…·C. Arrowsmith
This paper develops a toolkit for producing mutant and wild-type huntingtin proteins in eukaryotic systems to enable biochemical and structural studies of HD-related mutations.