D. McLeod

High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing

This paper develops and validates a high-throughput system for long-term optical measurement of peri-cellular oxygen in cardiac cells, showing dynamic oxygen changes and differences between hiPSC-CMs and fibroblasts.

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

This study identifies small molecule antagonists of RBBP4's top pocket, competes with protein and histone interactions, and reports the first crystal structure of RBBP4 with a small molecule.

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

The formation of microbial exoskeletons is driven by a controlled calcium-concentrating subcellular niche

This paper identifies a calcium-accumulating subcellular niche in bacteria that drives biofilm mineralization, showing its conservation across species and potential as a drug target.

Responses of the putative trachoma vector, Musca sorbens, to volatile semiochemicals from human faeces

This study identifies volatile semiochemicals in human faeces that attract Musca sorbens, a trachoma vector, suggesting potential for developing chemical lures to control the species.