Acquired epithelial WNT secretion drives niche independence of developing gastric cancer
I. Teriyapirom, J. Kim, H. Lee, S. R. Merker, A. Andersson-Rolf, S. R. Jahn, A.-M. Ada, S.-M. Kim, J. Y. Lim, T. Schmaeche, N. Wetterling, S. Stegert, J.-Y. Park, J.-H. Cheong, H. Kim, , B.-K. Koo
The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.
bioRxiv · Feb 24, 2023 · PreprintCancer Biology