Cancer BiologybioRxivPreprint
Acquired epithelial WNT secretion drives niche independence of developing gastric cancer
I. Teriyapirom, J. Kim, H. Lee…·B.-K. Koo
The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.