Minor intron splicing efficiency increases with the development of lethal prostate cancer
A. Augspach, K. Drake, L. Roma, E. Qian, S. R. Lee, D. Clarke, S. Kumar, M. Jaquet, J. Gallon, M. Bolis, J. Triscott, J. A. Galvan, Y. Chen, G. Thalmann, M. Kruithof-de Julio, , M. A. Rubin
The paper shows that minor intron splicing efficiency increases in castration-resistant prostate cancer and that inhibiting the minor spliceosome reduces tumor burden.
bioRxiv · Dec 9, 2021 · PreprintCancer Biology