R. Bareja

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

Obesity promotes breast epithelium DNA damage in BRCA mutation carriers

The paper shows that obesity increases DNA damage in breast epithelium of BRCA mutation carriers and suggests targeting estrogen or metabolic dysfunction may reduce breast cancer risk.

The evolution of genomic, transcriptomic, and single-cell protein markers of metastatic upper tract urothelial carcinoma

The paper examines genomic, transcriptomic, and single-cell protein markers in metastatic upper tract urothelial carcinoma, finding discordant genomic alterations but stable molecular and immune subtypes between primary and metastatic tumors.

A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

The paper identifies a nuclear cAMP microdomain that suppresses tumor growth by inhibiting YAP in the Hippo pathway.

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.