N. Dephoure

This study examines how liver and brain cells use autophagy under normal and nutrient-deprived conditions, revealing tissue-specific differences in organelle turnover and cargo capture.

This study shows that radiation therapy promotes unsaturated fatty acid accumulation in glioblastoma, enhancing survival by reducing ER stress, and that targeting lipid metabolism could improve treatment outcomes.

The paper uses proximity proteome mapping to show that anti-PD-L1 therapy disrupts specific PD-L1-dependent pathways in EGFR-mutant lung cancer cells, leading to altered cell migration and EGFR stability.

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

The paper introduces a cost-effective and robust phosphopeptide enrichment method using calcium titanate, achieving results comparable to TiO2-based methods.

The paper identifies a conserved signaling network that responds to sphingolipid delivery to the plasma membrane in budding yeast, linking membrane growth to cell cycle and ribosome biogenesis.