Author

A. Ayaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

J. B. Kinney· 2 shared A. D. Davidson· 1 shared A. Fernandez-Sesma· 1 shared A. R. Krainer· 1 shared C. Marti-Gomez· 1 shared D. Jones· 1 shared D. M. McCandlish· 1 shared K. Maringer· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

J. B. Kinney

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Author profile →

3 papers

Recent·Most cited

Specificity, synergy, and mechanisms of splice-modifying drugs

Y. Ishigami, M. S. Wong, C. Marti-Gomez, A. Ayaz, M. Kooshkbaghi, S. Hanson, D. M. McCandlish, A. R. Krainer, J. B. Kinney

This study develops quantitative models to understand how splice-modifying drugs work, showing drug-specific mechanisms and revealing widespread drug synergy and cooperativity.

bioRxiv · Dec 30, 2022Biophysics

Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells

T. A. Russell, A. Ayaz, A. D. Davidson, A. Fernandez-Sesma, K. Maringer

The paper develops immune assays to study NF-κB activation in Aedes aegypti cells, finding that viral RNA triggers the Imd pathway but not the Toll pathway.

bioRxiv · Jun 30, 2020Immunology

Measuring cis-regulatory energetics in living cells using allelic manifolds

T. Forcier, A. Ayaz, M. S. Gill, D. Jones, R. Phillips, J. B. Kinney

The paper introduces a method to measure the Gibbs free energy of TF-DNA and TF-TF interactions in living cells using allelic manifolds and reporter assays, achieving precision of ~0.1 kcal/mol.

bioRxiv · Nov 19, 2018Biophysics