D. Jones

Granzyme K drives a newly-intentified pathway of complement activation

This study identifies granzyme K as a driver of a novel complement activation pathway independent of classical, lectin, or alternative pathways.

Characteristics of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2 in neutralization escape, infectivity and membrane fusion

This study evaluates neutralization resistance, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 subvariants SLip, FLiRT, and KP.2, identifying key mutations affecting antibody sensitivity and spike function.

Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion

This study compares immune evasion, antigenicity, and cell-cell fusion properties of SARS-CoV-2 BA.2.87.1 and JN.1 variants, finding BA.2.87.1 shows less neutralization escape and higher infectivity than JN.1 and XBB.1.5.

Lymphatic muscle cells are unique cells that undergo aging induced changes

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

The evolution of the duckweed ionome mirrors losses in structural complexity

This study examines the evolution of the duckweed ionome across species with varying structural complexity, finding decreasing calcium and magnesium levels and increased cadmium accumulation in rootless species.

Immune Evasion, Infectivity, and Fusogenicity of SARS-CoV-2 Omicron BA.2.86 and FLip Variants

This study compares immune evasion, infectivity, and fusogenicity of SARS-CoV-2 variants BA.2.86 and FLip using neutralization assays and cell-based experiments.

Immune Evasion and Membrane Fusion of SARS-CoV-2 XBB Subvariants EG.5.1 and XBB.2.3

This study evaluates neutralization and fusion activity of SARS-CoV-2 XBB subvariants EG.5.1 and XBB.2.3, showing reduced neutralization by bivalent vaccines and highlighting the need for updated vaccine formulations.

Optimising CNT-FET Biosensor Design: Predictive Modelling of Biomolecular Electrostatic Gating and its Application to Beta-Lactamase Detection

This study models protein electrostatic interactions with CNT-FETs and demonstrates detection of beta-lactamases using BLIP2 receptors.

Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

Extraordinary Evasion of Neutralizing Antibody Response by Omicron XBB.1.5, CH.1.1 and CA.3.1 Variants

This study evaluates neutralizing antibody escape by Omicron subvariants XBB.1.5, CH.1.1, and CA.3.1, showing near-complete escape from mRNA vaccines but partial rescue with bivalent boosters.

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

Distinct Neutralizing Antibody Escape of SARS-CoV-2 Omicron Subvariants BQ.1, BQ.1.1, BA.4.6, BF.7 and BA.2.75.2

This study evaluates neutralization resistance and immune evasion mechanisms of SARS-CoV-2 Omicron subvariants against various sera, identifying key mutations driving resistance.

N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability.

This study shows glycosylation increases the rigidity of horseradish peroxidase, enhancing its activity and stability through structural changes.

Optimisation and Pre-clinical Demonstration of Temporal Diffusion Ratio for Imaging Restricted Diffusion

This paper optimizes and pre-clinically demonstrates Temporal Diffusion Ratio (TDR) for imaging restricted diffusion, showing improved contrast and correlation with axon diameter in rat spinal cord.

Genome-wide analysis of dendritic cell differentiation

This study uses a genome-wide CRISPR/Cas9 screen to identify regulators of dendritic cell differentiation in a Flt3L-dependent murine progenitor cell line.

The arthropod associates of 155 North American cynipid oak galls

The paper reports rearing records of arthropods from over 527,000 oak galls, identifying 151,075 animals and providing ecological and phylogenetic insights into gall-associated taxa.

Multiplexed Single-Molecule Epigenetic Analysis of Plasma-Isolated Nucleosomes for Cancer Diagnostics

The paper develops EPINUC, a single-molecule assay for analyzing plasma nucleosomes to detect cancer with high accuracy, including early-stage colorectal cancer and determining tumor origin.

Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome

This study shows that mechanical loading of cranial joints in Crouzon syndrome mice delays craniosynostosis and reduces brachycephalic skull morphology.

H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape

This study shows H3-K27M mutations alter chromatin marks by affecting PRC2 and MLL1 interactions, leading to bivalent chromatin and supporting glioma development.

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

The paper shows that DDR heterogeneity in ovarian cancer predicts patient outcomes and chemotherapy response by analyzing DDR pathway interactions and constructing predictive DDR signatures.

Beyond taxonomic identification: integration of ecological responses to a soil bacterial 16S rRNA gene database.

The paper creates a soil-specific 16S rRNA gene database with ecological traits and demonstrates its utility in predicting pH responses of soil bacterial taxa.

Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation

This study determines the structure of a cold-active esterase and identifies increased substrate accessibility and water entropy tolerance as the main drivers of its cold adaptation.

Structure guided engineering of a cold active esterase expands substrate range though a stabilisation mutation that allows access to a buried water chamber

The paper engineers a cold-active esterase to expand its substrate range by stabilizing a structural mutation that allows access to a buried water chamber.

Extending the Near Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging

This paper develops InP quantum dots with tunable NIR emission for in vivo imaging, overcoming synthesis challenges and demonstrating multiplexed lymph node imaging in mice.

Trophic position derived from amino-acid nitrogen isotopes reflect physiological status of both predator and prey over four decades

The paper uses nitrogen isotope analyses in amino acids to show that trophic position estimates in cod and herring are influenced by physiological status and environmental factors over four decades.

Darwin was right, in any given field, the spatial variability of earthworm communities in pastures isnt driven by measurable soil properties.

This study shows that earthworm abundance in pastures is mainly influenced by local biological factors rather than soil properties, but national patterns correlate with environmental factors.

Stalling chromophore maturation of the fluorescent protein Venus reveals the molecular basis of the final oxidation step

The paper identifies the molecular mechanism of the final oxidation step in Venus fluorescent protein maturation by using crystal structures and spectroscopy.

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

The effect of proximity on the function and energy transfer capability of fluorescent protein pairs

This study shows that dimerization of fluorescent protein pairs alters their fluorescent properties and FRET efficiency, challenging assumptions about FP-based proximity sensing.