BiochemistrybioRxiv
Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation
A. G. Grieve, Y.-C. Yeh, L. Zarcone…·M. Freeman
The paper identifies RHBDL2 as a rhomboid protease that surveils and cleaves active Orai1 to prevent inappropriate CRAC channel activation, maintaining proper T cell signaling.
DOI 10.1016/j.molcel.2021.10.025