N. Johnson

Quercetin selectively reduces expanded repeat RNA levels in models of myotonic dystrophy

Quercetin reduces toxic RNA levels and rescues MBNL-dependent mis-splicing in DM1 and DM2 models.

Using correlative and mechanistic species distribution models to predict vector-borne disease risk for the current and future environmental and climatic change: a case study of West Nile Virus in the UK.

This study predicts future West Nile Virus risk in the UK by combining species distribution models of vectors, hosts, and climate scenarios.

Predicting West Nile Virus risk across Europe for the current and future conditions

This study predicts West Nile Virus risk across Europe using species distribution modeling, showing increased risk in some areas and decreased risk in others under future climate scenarios.

UK mosquitoes are competent to transmit Usutu virus at native temperatures

This study assesses the vector competence of UK mosquitoes for the local Usutu virus strain at regional temperatures, finding several species capable of transmitting the virus.

Transovarial transmission in field caught mosquitoes identifies a mechanism for the establishment of Usutu virus in a temperate country

Building a barrier: investigating the functional role and evolution of induced trichome production

This study investigates whether herbicide exposure induces changes in trichome traits in velvetleaf and links these changes to herbicide resistance and fitness.

Small RNA Analysis of Virus-virus Interaction between Two Orthotospoviruses

This study uses small RNA sequencing to investigate how INSV affects TSWV processing and plant responses during their antagonistic interaction.

Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice

This study shows that muscle-specific Nox4 knockout in mice improves muscle contractility after spinal cord injury, though force remains lower than in uninjured controls.

Dicamba drift alters patterns of chewing herbivory in three common agricultural weeds

This study shows dicamba drift increases chewing herbivory in some weeds but changes herbivory types, affecting plant-herbivore interactions.

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

This study identifies RNF168-mediated recruitment of the BRCA1-PALB2 complex to DNA damage through BARD1 and mUb-H2A.

Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking

This study demonstrates that integrating ligand blocking into LIBRA-seq improves the efficiency of identifying potent SARS-CoV-2 neutralizing antibodies.

Clathrin adaptors mediate two sequential pathwaysof intra-Golgi recycling

The paper identifies two sequential intra-Golgi recycling pathways mediated by AP-1 and Ent5 clathrin adaptors, explaining the polarized distribution of Golgi transmembrane proteins.

Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

This paper introduces a deep learning method to improve high-content screening for Alzheimer's disease therapeutics by generating predicted fluorescent signals from alternative markers.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Respiratory disease in cats associated with human-to-cat transmission of SARS-CoV-2 in the UK

This study reports two cases of SARS-CoV-2 infection in UK cats linked to human-to-cat transmission, showing mild to severe respiratory disease and genetic variation in the viral genome.

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

The paper identifies RHBDL2 as a rhomboid protease that surveils and cleaves active Orai1 to prevent inappropriate CRAC channel activation, maintaining proper T cell signaling.

Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses

This study sequences 22 louping ill virus isolates to analyze genomic diversity and evolutionary history, finding low diversity, limited positive selection, and challenges in estimating molecular clock rates for tick-borne flaviviruses.

Biotic and abiotic factors predict the biogeography of soil microbes in the Serengeti

The paper investigates how biotic and abiotic factors shape soil microbial biogeography in the Serengeti by analyzing 16S rRNA amplicon data from a herbivore removal experiment.

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

Coordinated development of the mouse extrahepatic bile duct: implications for neonatal susceptibility to biliary injury

This study identifies four key anatomical and functional differences between neonatal and adult mouse extrahepatic bile ducts that may explain their susceptibility to injury.