Author

A. G. Grieve

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Freeman· 3 shared A. B. Parekh· 1 shared A. J. Ryan· 1 shared B. Sieber· 1 shared F. Lu· 1 shared J. Breuning· 1 shared K. Strisovsky· 1 shared L. Zarcone· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

M. Freeman

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Author profile →

3 papers

Recent·Most cited

iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis

B. Sieber, F. Lu, S. M. Stribbling, A. G. Grieve, A. J. Ryan, M. Freeman

This study shows that iRhom2 promotes KRAS-driven oncogenesis by enhancing ADAM17-dependent shedding of ERBB ligands through phosphorylation and 14-3-3 protein recruitment.

bioRxiv · Aug 6, 2021Cancer Biology

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

A. G. Grieve, Y.-C. Yeh, L. Zarcone, J. Breuning, N. Johnson, K. Strisovsky, M. H. Brown, A. B. Parekh, M. Freeman

The paper identifies RHBDL2 as a rhomboid protease that surveils and cleaves active Orai1 to prevent inappropriate CRAC channel activation, maintaining proper T cell signaling.

bioRxiv · Apr 4, 2020Biochemistry

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

U. Künzel, A. G. Grieve, Y. Meng, S. A. Cowley, M. Freeman

This study identifies FRMD8 as a stabilizer of the iRhom2/ADAM17 complex, essential for ADAM17-mediated shedding of cytokines and growth factors.

bioRxiv · Jan 30, 2018Biochemistry