Author

K. Strisovsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Adrain· 3 shared D. Jakubec· 2 shared E. Burbridge· 2 shared P. Domingos· 2 shared A. Amin· 1 shared A. B. Parekh· 1 shared A. Barros· 1 shared A. Bileck· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersPhysiology

C. Adrain

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

M. L. Abramsson, R. A. Corey, J. L. Skerle, L. J. Persson, O. Anden, A. O. Oluwole, R. J. Howard, E. Lindahl, C. V. Robinson, K. Strisovsky, E. G. Marklund, D. Drew, P. J. Stansfeld, M. Landreh

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

bioRxiv · May 27, 2024Biochemistry

Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis

A. Amin, M. Badenes, J. Tueshaus, E. de Carvalho, E. Burbridge, P. Faisca, K. Travnickova, A. Barros, S. Carobbio, P. Domingos, A. Vidal-Puig, L. F. Moita, S. Maguire, K. Strisovsky, S. F. Lichtenthaler, C. Adrain

This study identifies SEMA4B as an ADAM17-cleaved inhibitor of adipocyte thermogenesis, showing it dampens thermogenic responses and protects against obesity.

bioRxiv · Oct 11, 2022 · PreprintPhysiology

EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel

C. J. Gaspar, L. C. Vieira, J. C. Christianson, D. Jakubec, K. Strisovsky, C. Adrain, P. Domingos

The paper identifies Xport-A as an essential chaperone for rhodopsin-1 and TRP channel biogenesis, showing EMC-dependent membrane insertion is required for its function.

bioRxiv · Feb 1, 2021Cell Biology

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

A. G. Grieve, Y.-C. Yeh, L. Zarcone, J. Breuning, N. Johnson, K. Strisovsky, M. H. Brown, A. B. Parekh, M. Freeman

The paper identifies RHBDL2 as a rhomboid protease that surveils and cleaves active Orai1 to prevent inappropriate CRAC channel activation, maintaining proper T cell signaling.

bioRxiv · Apr 4, 2020Biochemistry

Dimerization of rhomboid protease RHBDL2 in lipid membranes addressed by FRET with MC simulations

J. Škerle, J. Humpolíčková, P. Rampírová, E. Poláchová, L. Adámková, A. Suchánková, D. Jakubec, K. Strisovsky

This study uses FRET and FCS with Monte Carlo simulations to analyze RHBDL2 dimerization in lipid membranes, finding no evidence for stable oligomers.

bioRxiv · Mar 31, 2018 · PreprintBiophysics

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

I. Oikonomidi, E. Burbridge, M. Cavadas, G. Sullivan, D. Clancy, B. Collis, J. Brezinova, J. Humpolickova, T. Hu, A. Bileck, C. Gerner, A. Bolado, A. von Kriegsheim, K. Strisovsky, S. J. Martin, C. Adrain

This study identifies iTAP as a novel iRhom interactor that stabilizes iRhom and TACE, essential for TNF secretion, and shows its role in regulating inflammation.

bioRxiv · Jan 30, 2018Biochemistry