Cryo-EM Reveals Ligand Induced Allostery Underlying InsP3R Channel Gating
G. Fan, M. R. Baker, Z. Wang, A. B. Serysheva, S. J. Ludtke, M. L. Baker, I. I. Serysheva
The paper presents cryo-EM structures of InsP3R1 in activated and apo-states, revealing ligand-induced conformational changes that underlie channel gating.
bioRxiv · Jul 23, 2018Biophysics