Direct tissue sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
D. Amaral-Silva, R. C. Torrao, R. Torres, S. Falcao, M. J. Goncalves, M. P. Araujo, M. J. Martins, C. Lopes, A. Neto, J. Marona, T. Costa, W. Castelao, A. B. Silva, I. Silva, M. H. Lourenco, , H. Soares
The paper identifies TLR4+ Tfh-like cells in RA patients that switch from producing IL-21 to IL-17 upon joint exposure, contributing to tissue damage.
bioRxiv · Feb 19, 2021Immunology