R. Torres

Separate domains of the Arabidopsis ENHANCER OF PINOID drive its own polarization and recruit PIN1 to the plasma membrane

This paper identifies domains in Arabidopsis ENP that drive its own polarization and recruit PIN1 to the plasma membrane, revealing a PID-independent mechanism for PIN1 activity.

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

Nanometer-scale views of visual cortex reveal anatomical features of primary cilia poised to detect synaptic spillover

This study examines primary cilia in mouse visual cortex using electron microscopy, revealing their distribution, structure, and proximity to synapses.

Direct tissue sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

The paper identifies TLR4+ Tfh-like cells in RA patients that switch from producing IL-21 to IL-17 upon joint exposure, contributing to tissue damage.

DisA limits RecA- and RadA/Sms-mediated replication fork remodelling to prevent genome instability

This study shows DisA inhibits RadA/Sms ATPase and helicase activities to prevent genome instability during Bacillus subtilis spore revival.

BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB.

This study identifies microRNA-mediated suppression of AURKB as a mechanism by which BRAFV600E induces reversible mitotic arrest in human melanocytes, contributing to nevus formation.

In vitro and In vivo Genetic Disease Modelling via NHEJ precise deletions using CRISPR/Cas9

The paper demonstrates that using two guideRNAs at optimal distance and orientation with CRISPR/Cas9 enables precise deletions for creating genetically reproducible disease models in human and mouse cells.

The temporal dynamics of background selection in non-equilibrium populations

The paper uses forward simulations to study how background selection affects genetic diversity in non-equilibrium populations over time, finding that initial dynamics often oppose long-term trends and classical models are inadequate.

Modelling marine larval dispersal: a cautionary deep-sea tale for ecology and conservation

This paper compares two larval dispersal models with an estimate to show greater model variability and advocates for groundtruthing before using predictions in marine conservation.

A machine-learning classifier trained with microRNA ratios to distinguish melanomas from nevi

This study develops a machine learning classifier using microRNA ratios to distinguish melanomas from nevi, achieving 83% sensitivity and 71-83% specificity across multiple datasets.

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

Human demographic history has amplified the effects of background selection across the genome

The paper investigates how non-equilibrium demographic processes amplify background selection effects on genetic diversity in human populations, showing greater diversity loss in non-African populations.