C. Lopes

The Dystrophin-Dystroglycan complex ensures cytokinesis efficiency in Drosophila epithelia

The paper identifies Dystrophin-Dystroglycan as essential for cytokinesis efficiency in Drosophila epithelia by regulating ring contraction and preventing membrane regression.

Assimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum

This study estimates assimilation efficiencies and elimination rates of Ag, Cd, and Zn in Gammarus fossarum via trophic pathways using pulse-chase-feeding experiments.

A conformational-dependent interdomain redox relay at the core of Protein Disulfide Isomerase activity

This study elucidates the mechanism of PDIA1 activity through an interdomain redox relay, showing how its two active sites cooperate to catalyze disulfide bond formation and resolution.

Chemical effects on ecological interactions within a model-experiment loop

The paper develops a dynamic model to assess contaminant effects on a micro-ecosystem and uses Bayesian inference to estimate parameters from experimental data, identifying direct and indirect ecological impacts of cadmium.

Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals

This paper presents a unified framework for solving Physiologically-Based Kinetic (PBK) models using matrix ordinary differential equations, enabling flexible modeling of chemical absorption, distribution, metabolism, and excretion across organisms.

Improvements in estimating bioaccumulation metrics in the light of toxicokinetics models and Bayesian inference

This paper improves bioaccumulation metric estimation by using Bayesian inference and a meta-analysis of toxicokinetic data to propose using the 75th percentile of uncertainty intervals for classification.

Shared hotspot mutations in spontaneously arising cancers position dog as an unparalleled comparative model for precision therapeutics

This study identifies shared hotspot mutations in canine and human cancers, highlighting dogs as a valuable model for precision cancer therapeutics.

'rbioacc': an R-package to analyse toxicokinetic data

rbioacc is an R-package that analyzes toxicokinetic data from bioaccumulation tests, providing Bayesian parameter estimates and bioaccumulation metrics with uncertainty.

Generic solving of one-compartment toxicokinetic models

This paper provides the analytical solution for one-compartment toxicokinetic models, enabling better parameter estimation and environmental risk assessment.

Taking full advantage of modelling to better assess environmental risk due to xenobiotics

The paper reviews dose-response models and introduces MOSAIC, a tool for environmental risk assessment using TKTD models to improve pesticide risk evaluation for aquatic organisms.

Direct tissue sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

The paper identifies TLR4+ Tfh-like cells in RA patients that switch from producing IL-21 to IL-17 upon joint exposure, contributing to tissue damage.

New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms

The paper introduces a web tool, MOSAICbioacc, for calculating bioaccumulation metrics with uncertainty, designed to assist ecotoxicologists and regulators in analyzing complex exposure scenarios.

Comparison Between Normobaric Hypoxia Altitude Simulation Test and Altitude Hypoxia Predictive Equations in Cystic Fibrosis Patients

The paper compares normobaric hypoxia altitude simulation test results with five predictive equations in cystic fibrosis patients to assess their accuracy in predicting in-flight hypoxia.

TriPer, an optical probe tuned to the endoplasmic reticulum, tracks H2O2 consumption by glutathione

The paper develops TriPer, an optical probe that detects H2O2 in the ER, revealing glutathione's role in H2O2 turnover during protein folding.